AMD MI250 vs Nvidia RTX PRO 4500

The MI250 has 4x the memory and 3.6x the bandwidth.

At a glance

Memory

4x more on MI250

MI250: 128 GB

RTX PRO 4500: 32 GB

Memory bandwidth

3.6x higher on MI250

MI250: 3,200 GB/s

RTX PRO 4500: 896 GB/s

Cheapest on-demand

MI250 is not sold on demand

MI250: --

RTX PRO 4500: $0.35 /GPU/hr

Price comparison

Median price per GPU per hour by billing type, with the cheapest listing under it.

Billing	MI250	RTX PRO 4500
On-demand	No on-demand listings	$0.82 /GPU/hr from $0.35
Reserved	-- /GPU/hr from $1.30 (12 mo)	-- /GPU/hr from $0.33 (1 mo)
Spot	No spot listings	-- /GPU/hr from $0.24

Heads up: A provider's own page may quote a different figure, for example on tax, region or a promotion. A monthly-only plan shows a derived hourly rate. Medians are across providers, one vote each, so a large catalog does not outweigh a small one. No median for reserved on the MI250 and reserved and spot on the RTX PRO 4500: we only show one when at least 3 providers list the GPU on that billing type. Verify before provisioning. More on how we price.

Price history

MI250 vs RTX PRO 4500 price history

Weekly median on-demand price per GPU per hour

Last 12 months

Aggregating historical prices...

Specs comparison

Spec	MI250	RTX PRO 4500	Difference
Memory
Capacity	128 GB HBM2e	32 GB GDDR7	4x more on MI250
Bandwidth	3,200 GB/s	896 GB/s	3.6x higher on MI250
Bus width	8,192-bit	256-bit	32x wider on MI250
Compute · dense
FP4	Not supported	808.5 TFLOPS	RTX PRO 4500 only
FP8	Not supported	404.3 TFLOPS	RTX PRO 4500 only
FP16 / BF16	362.1 TFLOPS	202.1 TFLOPS	79% higher on MI250
INT8	362.1 TOPS	404.3 TOPS	12% higher on RTX PRO 4500
FP32	90.5 TFLOPS	51 TFLOPS	77% higher on MI250
FP64	45.3 TFLOPS	Not supported	MI250 only
Platform
Interconnect	Infinity Fabric 400 GB/s	PCIe only	Infinity Fabric on MI250 only
Board power	500 W	200 W	2.5x higher on MI250
Released	Q4 2021	Q1 2025	3 years newer on RTX PRO 4500
Precision
Supported formats	FP16BF16FP32FP64INT4INT8	FP4FP8FP16BF16TF32FP32INT8

Compute: Vendor peak figures, dense and per GPU. Not measured throughput.

Source: MI250 datasheet and RTX PRO 4500 datasheet.

Where to rent them

Providers that rent these GPUs, with each one's cheapest rate. No provider we track offers both right now.

Provider	MI250	RTX PRO 4500
Cirrascale USA	$1.30 /GPU/hr Reserved	--
Vast.ai USA	--	$0.35 /GPU/hr On-demand
GPU.ai UAE	--	$0.35 /GPU/hr On-demand
Runpod USA	--	$0.72 /GPU/hr On-demand
Massed Compute USA	--	$0.92 /GPU/hr On-demand
EmpirioLabs AI USA	--	$1.40 /GPU/hr On-demand
AWS USA	--	$2.52 /GPU/hr On-demand