AMD MI250
vs
Nvidia RTX PRO 4000
A data center GPU against a workstation card, one CDNA2 and one Blackwell: 128 GB HBM2e against 24 GB GDDR7, 4.8x the memory bandwidth on the MI250, and Infinity Fabric 400 GB/s on the MI250 where the RTX PRO 4000 is PCIe only.
At a glance
Updated 8 minutes ago- Memory
- 128 GB
- HBM2e
- Memory bandwidth
- 3.20 TB/s
- From
- --
- Not sold on demand · 1 provider
- Memory
- 24 GB
- GDDR7
- Memory bandwidth
- 672 GB/s
- From
- $20.00 /GPU/hr
- 3 providers
Price comparison
Cheapest listed price per GPU per hour by billing type, and the median across providers.
| Billing | MI250 | RTX PRO 4000 | Difference |
|---|---|---|---|
| On-demand | Not sold on demand | $20.00 | |
| Spot | No spot listings | $13.33 | |
| Reserved | $1.30 | $0.26 | 5x more expensive on MI250 |
| Median | $1.50 | $20.00 | 13x more expensive on RTX PRO 4000 |
Median: Median across providers, one vote each, so a large catalog does not outweigh a small one.
Price history
MI250 vs RTX PRO 4000 price history
Weekly median on-demand price per GPU per hour
Specs comparison
| Spec | MI250 | RTX PRO 4000 | Difference |
|---|---|---|---|
| Memory | |||
| Capacity | 128 GB HBM2e | 24 GB GDDR7 | 5.3x more on MI250 |
| Bandwidth | 3,200 GB/s | 672 GB/s | 4.8x higher on MI250 |
| Bus width | 8,192-bit | 192-bit | 43x wider on MI250 |
| Compute · dense | |||
| FP4 | Not supported | 589 TFLOPS | RTX PRO 4000 only |
| FP8 | Not supported | 294.5 TFLOPS | RTX PRO 4000 only |
| FP16 / BF16 | 362.1 TFLOPS | 147.3 TFLOPS | 2.5x higher on MI250 |
| INT8 | 362.1 TOPS | 294.5 TOPS | 1.2x higher on MI250 |
| FP32 | 90.5 TFLOPS | 37 TFLOPS | 2.4x higher on MI250 |
| FP64 | 45.3 TFLOPS | Not supported | MI250 only |
| Platform | |||
| Interconnect | Infinity Fabric 400 GB/s | PCIe only | Infinity Fabric on MI250 only |
| Board power | 500 W | 145 W | 3.4x higher on MI250 |
| Released | Q4 2021 | Q1 2025 | 3 years newer on RTX PRO 4000 |
| Precision | |||
| Supported formats | FP16BF16FP32FP64INT4INT8 | FP4FP8FP16BF16TF32FP32INT8 | |
Compute: Vendor peak figures, dense and per GPU. Not measured throughput.
Source: MI250 datasheet and RTX PRO 4000 datasheet.
Where to rent them
Providers listing these GPUs, those with both first, so you can switch without moving clouds.
| Provider | MI250 /GPU/hr | RTX PRO 4000 /GPU/hr |
|---|---|---|
Cirrascale
|
Reserved (12mo) $1.30 | -- |
Vast.ai
|
-- | On-Demand $20.00 |
Database Mart
|
-- | Reserved (24mo) $0.26 |
Runpod
|
-- | Reservation on request |
Similar GPUs
Other comparisons in the same class.
Our data for AMD MI250 was last updated on Sept. 7, 2026, and for Nvidia RTX PRO 4000 on Sept. 7, 2026.