AMD MI350X vs Nvidia RTX PRO 4500

A data center GPU against a workstation card, one CDNA 4 and one Blackwell: 288 GB HBM3e against 32 GB GDDR7, 8.9x the memory bandwidth on the MI350X, and Infinity Fabric 1,075 GB/s on the MI350X where the RTX PRO 4500 is PCIe only.

At a glance

Memory

MI350X: 288 GB
RTX PRO 4500: 32 GB

9x more on MI350X

Memory bandwidth

MI350X: 8,000 GB/s
RTX PRO 4500: 896 GB/s

8.9x higher on MI350X

Cheapest on-demand

MI350X: --
RTX PRO 4500: $0.34 /GPU/hr

MI350X is not sold on demand

Price comparison

Median price per GPU per hour by billing type, with the cheapest listing under it.

Billing	MI350X	RTX PRO 4500
On-demand	No on-demand listings	$0.82 /GPU/hr from $0.34
Reserved	-- /GPU/hr from $4.76 (12 mo)	On request
Spot	-- /GPU/hr from $4.00	-- /GPU/hr from $0.19

Heads up: A provider's own page may quote a different figure, for example on tax, region or a promotion. A monthly-only plan shows a derived hourly rate. Medians are across providers, one vote each, so a large catalog does not outweigh a small one. No median for reserved and spot on the MI350X and spot on the RTX PRO 4500: we only show one when at least 3 providers list the GPU on that billing type. Verify before provisioning. More on how we price.

Price history

MI350X vs RTX PRO 4500 price history

Weekly median on-demand price per GPU per hour

Last 7 months

Aggregating historical prices...

Specs comparison

Spec	MI350X	RTX PRO 4500	Difference
Memory
Capacity	288 GB HBM3e	32 GB GDDR7	9x more on MI350X
Bandwidth	8,000 GB/s	896 GB/s	8.9x higher on MI350X
Bus width	8,192-bit	256-bit	32x wider on MI350X
Compute · dense
FP4	9,227.5 TFLOPS	808.5 TFLOPS	11x higher on MI350X
FP8	4,614 TFLOPS	404.3 TFLOPS	11x higher on MI350X
FP16 / BF16	2,309.6 TFLOPS	202.1 TFLOPS	11x higher on MI350X
INT8	4,614 TOPS	404.3 TOPS	11x higher on MI350X
FP32	144.2 TFLOPS	51 TFLOPS	2.8x higher on MI350X
FP64	72.1 TFLOPS	Not supported	MI350X only
Platform
Interconnect	Infinity Fabric 1,075 GB/s	PCIe only	Infinity Fabric on MI350X only
Board power	1,000 W	200 W	5x higher on MI350X
Released	Q2 2025	Q1 2025
Precision
Supported formats	FP4FP6FP8FP16BF16FP32FP64INT8	FP4FP8FP16BF16TF32FP32INT8

Compute: Vendor peak figures, dense and per GPU. Not measured throughput.

Source: MI350X datasheet and RTX PRO 4500 datasheet.

Where to rent them

Providers listing these GPUs, those with both first, so you can switch without moving clouds.

Provider	MI350X /GPU/hr	RTX PRO 4500 /GPU/hr
DigitalOcean	Reserved (12mo) $4.76	--
Vast.ai	--	On-Demand $0.34
GPU.ai	--	On-Demand $0.72
Runpod	--	On-Demand $0.72
Massed Compute	--	On-Demand $0.92
EmpirioLabs AI	--	On-Demand $1.40
AWS	--	On-Demand $2.52